Endocrine Abstracts

Introduction: Both GH deficiency (GHD) and male hypogonadism are thought to be associated with an increased cardiovascular morbidity and mortality which is at least partly attributed to higher Insulin resistance. Potential reversibility of increased risk factors after gonadal replacement was assessed in this study, by comparing replaced and unreplaced hypogonadal men with GHD.Subjects and methods: Seventy-seven hypogonadal adult male patients with GHD ha...

The inflammatory response in rat models of obesity and malnutrition was examined. Rats received standard chow (control), chow enriched with 30% lard (obese) or 70, 50, 40 and 40% of expected food intake weekly for 4 weeks (starved). The serum levels of cytokines were determined by ELISA, while the expression of cytokine mRNA in heart and liver was analyzed by real-time RT-PCR. The blood concentrations of pro-inflammatory cytokines (TNF, IL-1) and Th1 cytokine IFN-gamma were si...

The aim of the study was to investigate the influence of intracerebroventricular (ICV) injections of ghrelin on secretion of pro-inflammatory (TNF, IL-1, IFN-γ) and anti-inflammatory cytokines (TGF-β) in starved rats. Male Wistar rats (4 weeks old, 12 per group) were fed ad libitum or starved by caloric restriction (40% of chow consumed by their ad libitum fed controls from previous day) for 4 weeks. Afterwards, half of the animals in each group receive...

Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. Despite emaciation and avoidance of cholesterol-rich food, hypercholesterolaemia is a common feature. The aim of the study was to investigate the changes in lipid metabolism with weight gain in 17 severe AN patients aged 23.8±1.6 years (DSM-IV criteria). They were compared with age-matched cohorts of 11 healthy controls (22.5±3.9 years) before and after wei...

Growth hormone deficiency (GHD) impairs bone mass and strength. Androgen deficient men exhibit impaired bone mass, but the extent to which testosterone replacement can prevent this remains disputable. The aim of this study was to assess whether androgen deficiency presents an additional risk factor for bone health in male patients with GHD and whether this is correctable by testosterone substitution.A group of 81 male patients with GHD, not receiving GH ...

Previous studies have shown exaggerated ACTH and cortisol responses to ghrelin. Seven patients who were cured by transsphenoidal operation from CD were included in the study and tested with ghrelin (1 mcg/kg i.v.) before and six months after the operation. Their results were compared with eight healthy control subjects. Results are presented as mean±S.D. Mann–Whitney and Wilcoxon signed rank test were used for statistical analysis.<p class="abstext...

Background: Hypopituitary patients with untreated growth hormone deficiency (GHD) have increased fat mass, dyslipidaemia and insulin resistance. Inappropriately low thyroxine doses in patients with central hypothyroidism (CH) may also promote such clinical features.Objective: To examine metabolic outcome of thyroxine replacement in hypopituitary patients before and after GH replacement.Method: One thousand and six hundred and two p...

Obesity protects from osteoporosis. Bone remodeling and energy metabolism could be regulated by the adipocyte-derived hormone, leptin acting on osteoblasts though hypothalamic pathways. Hypothalamic lesions cause obesity. Since most of these patients are also hypopituitary with low IGF1 which could affect bone metabolism the aim of our study was to investigate whether obesity would protect them from osteoporosis.Three groups of patients were studied: (1)...

Anorexia nervosa (AN) is associated with bone loss due to weight loss, decreased caloric intake, amenorrhoea and behavioral changes. The most important predictor of the occurrence of bone loss is body weight (BMI <16.5 kg/m2). Previous studies suggested that many factors including effects of chronic undernutrition in AN patients is associated with a reduction of bone formation (osteocalcin-OC) uncoupled with increased resorption markers (crosslaps-CTx). The aim ...

COGHD may be of genetic origin associated with deficiency of other pituitary hormones. Non treatment with GH in these cases can cause metabolic and other disturbances. The aim of this research was examining consequences of non treated COGDH in three sisters with familial hypopituitarism. Three sisters 60-, 59- and 54-year-old with familial hypopituitarism (GH,TSH, gonadotropin and prolactin deficiency) which was diagnosed 46 years before were examined. Substitution therapy per...